Highly Strained Organophosphorus Compounds
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In our research on small, strained organophosphorus ring systems we became interested in the synthesis and applications of species that are even more strained than the parent phosphirane, by introducing an exocyclic double bond (methylenephosphirane), and by cyclopropyl spirofusion to the edge (e.g. phosphatriangulane) and side (phosphabicyclo[1.1.0]butane). These highly strained phosphorus heterocycles are fascinating species from a fundamental point of view. Moreover, they show intriguing reactivity and remarkably facile rearrangements resulting in a large spectrum of novel organophosphorus compounds. Thus, our interest not only lies in the efficient synthesis of these highly strained phosphacycles, but also in employing them as attractive building blocks for the synthesis of phosphine ligands. To achieve this aspiration, reactive intermediate chemistry is used, supported by high-level theoretical calculations, to develop new methodologies and versatile approaches toward applicable and processable building blocks creating unprecedented entries in organophosphorus chemistry.