TY - JOUR
T1 - Fast network oscillations in vitro exhibit a slow decay of temporal auto-correlations
AU - Poil, S.S.
AU - Jansen, R.
AU - van Aerde, K.I.
AU - Timmerman, J.
AU - Brussaard, A.B.
AU - Mansvelder, H.D.
AU - Linkenkaer-Hansen, K.
PY - 2011
Y1 - 2011
N2 - Ongoing neuronal oscillations invivo exhibit non-random amplitude fluctuations as reflected in a slow decay of temporal auto-correlations that persist for tens of seconds. Interestingly, the decay of auto-correlations is altered in several brain-related disorders, including epilepsy, depression and Alzheimer's disease, suggesting that the temporal structure of oscillations depends on intact neuronal networks in the brain. Whether structured amplitude modulation occurs only in the intact brain or whether isolated neuronal networks can also give rise to amplitude modulation with a slow decay is not known. Here, we examined the temporal structure of cholinergic fast network oscillations in acute hippocampal slices. For the first time, we show that a slow decay of temporal correlations can emerge from synchronized activity in isolated hippocampal networks from mice, and is maximal at intermediate concentrations of the cholinergic agonist carbachol. Using zolpidem, a positive allosteric modulator of GABA
AB - Ongoing neuronal oscillations invivo exhibit non-random amplitude fluctuations as reflected in a slow decay of temporal auto-correlations that persist for tens of seconds. Interestingly, the decay of auto-correlations is altered in several brain-related disorders, including epilepsy, depression and Alzheimer's disease, suggesting that the temporal structure of oscillations depends on intact neuronal networks in the brain. Whether structured amplitude modulation occurs only in the intact brain or whether isolated neuronal networks can also give rise to amplitude modulation with a slow decay is not known. Here, we examined the temporal structure of cholinergic fast network oscillations in acute hippocampal slices. For the first time, we show that a slow decay of temporal correlations can emerge from synchronized activity in isolated hippocampal networks from mice, and is maximal at intermediate concentrations of the cholinergic agonist carbachol. Using zolpidem, a positive allosteric modulator of GABA
U2 - 10.1111/j.1460-9568.2011.07748.x
DO - 10.1111/j.1460-9568.2011.07748.x
M3 - Article
SN - 0953-816X
VL - 34
SP - 394
EP - 403
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
IS - 3
ER -