Abstract
By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we performed a genome-wide association study (GWAS) comparing 403 unrelated nonagenarians from long-living families included in the Leiden Longevity Study (LLS) and 1670 younger population controls. The strongest candidate SNPs from this GWAS have been analyzed in a meta-analysis of nonagenarian cases from the Rotterdam Study, Leiden 85-plus study, and Danish 1905 cohort. Only one of the 62 prioritized SNPs from the GWAS analysis (P<1×10
Original language | English |
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Pages (from-to) | 686-698 |
Journal | Aging Cell |
Volume | 10 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2011 |
Cohort Studies
- Netherlands Twin Register (NTR)