Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

K. Estrada, U. Styrkarsdottir, E. Evangelou, Y.H. Hsu, E.L. Duncan, E.E. Ntzani, L. Oei, O.M.E. Albagha, N. Amin, J.P. Kemp, D.L. Koller, G. Li, C.T. Liu, R.L. Minster, A. Moayyeri, L. Vandenput, D. Willner, S.M. Xiao, L.M. Yerges-Armstrong, H.F. ZhengN. Alonso, J. Eriksson, C.M. Kammerer, S.K. Kaptoge, P.J. Leo, G. Thorleifsson, S.G. Wilson, J.F. Wilson, V. Aalto, M. Alen, A.K. Aragaki, T. Aspelund, J.R. Center, Z. Dailiana, DJ Duggan, M. Garcia, N. Garcia-Giralt, S. Giroux, G. Hallmans, L.J. Hocking, L.B. Husted, K.A. Jameson, R. Khusainova, G.S. Kim, C. Kooperberg, T. Koromila, M. Kruk, M. Laaksonen, A.Z. LaCroix, S.H. Lee, P.C. Leung, J.R. Lewis, L. Masi, S. Mencej-Bedrac, T.V. Nguyen, X. Nogues, M.S. Patel, J. Prezelj, L.M. Rose, S. Scollen, K. Siggeirsdottir, A.V. Smith, O. Svensson, S. Trompet, O. Trummer, N.M. van Schoor, J. Woo, K. Zhu, S. Balcells, M.L. Brandi, B.M. Buckley, S.L. Cheng, C. Christiansen, C. Cooper, G. Dedoussis, I. Ford, M. Frost, D. Goltzman, J. Gonzalez-Macias, M. Kahonen, M. Karlsson, E. Khusnutdinova, J.M. Koh, P. Kollia, B.L. Langdahl, W.D. Leslie, P.T.A.M. Lips, O. Ljunggren, R.S. Lorenc, J. Marc, D. Mellstrom, B. Obermayer-Pietsch, J.M. Olmos, U. Pettersson-Kymmer, D.M. Reid, J.A. Riancho, P.M. Ridker, F. Rousseau, P.E. Slagboom

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10
    Original languageEnglish
    Pages (from-to)491-501
    JournalNature Genetics
    Volume44
    Issue number5
    DOIs
    Publication statusPublished - 2012

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