Developmental toxicity and endocrine disrupting potency of 4-azapyrene, benzo(b)fluorene and retene in the zebrafish Danio rerio.

A. Hawliczek, B. Nota, P. Cenijn, J. Kamstra, B. Pieterse, R.. Winter, K. Winkens, H. Hollert, H. Segner, J. Legler

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

This study examined the developmental toxicity of the polycyclic aromatic hydrocarbons (PAHs) 11H-benzo(b)fluorene (BBF) and 4-azapyrene (AP) in comparison to the known teratogen retene. Developmental toxicity assays were performed in zebrafish embryos exposed for 120h. BBF and retene induced a similar dioxin-like phenotype, whereas AP showed distinct effects, particularly craniofacial malformations. Microarray analysis revealed that for BBF and retene, drug metabolism pathways were induced, which were confirmed by subsequent studies of cyp1a gene expression. For AP, microarray analysis revealed the regulation of genes involved in retinoid metabolism and hematological functions. Studies with a panel of CALUX
Original languageEnglish
Pages (from-to)213-223
JournalReproductive Toxicology
Volume33
Early online date20 Nov 2011
DOIs
Publication statusPublished - 2012

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