The expanded octarepeat domain selectively binds prions and disrupts homomeric prion protein interactions

S. R. Leliveld, R.T. Dame, G.J.L. Wuite, L. Stitz, C. Korth

Research output: Contribution to JournalArticleAcademicpeer-review

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Abstract

Insertion of additional octarepeats into the prion protein gene has been genetically linked to familial Creutzfeldt Jakob disease and hence to de novo generation of infectious prions. The pivotal event during prion formation is the conversion of the normal prion protein (PrP
Original languageEnglish
Pages (from-to)3268-3275
JournalJournal of Biological Chemistry
Volume281
Issue number6
DOIs
Publication statusPublished - 2006

Bibliographical note

The expanded octarepeat domain selectively binds prions and disrupts homomeric prion protein interactions

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