TY - JOUR
T1 - T-Screen as a tool to identify thyroid hormone receptor active compounds
AU - Gutleb, A.C.
AU - Meerts, I.A.T.M.
AU - Bergsma, J.H.
AU - Schriks, M.
AU - Murk, A.J.
PY - 2004
Y1 - 2004
N2 - The T-Screen represents an in vitro bioassay based on thyroid hormone dependent cell proliferation of a rat pituitary tumour cell line (GH3) in serum-free medium. It can be used to study interference of compounds with thyroid hormone at the cellular level, thus bridging the gap between limitations of assays using either isolated molecules (enzymes, transport proteins) or complex in vivo experiments with all the complex feedback mechanisms present. Compounds are tested both in the absence and presence of thyroid hormone (EC
AB - The T-Screen represents an in vitro bioassay based on thyroid hormone dependent cell proliferation of a rat pituitary tumour cell line (GH3) in serum-free medium. It can be used to study interference of compounds with thyroid hormone at the cellular level, thus bridging the gap between limitations of assays using either isolated molecules (enzymes, transport proteins) or complex in vivo experiments with all the complex feedback mechanisms present. Compounds are tested both in the absence and presence of thyroid hormone (EC
U2 - 10.1016/j.etap.2004.06.003
DO - 10.1016/j.etap.2004.06.003
M3 - Article
SN - 1382-6689
VL - 19
SP - 231
EP - 238
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
ER -