Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transhyretin: a metabolite of octachlorostyrene

C.D. Sandau, I.A.T.M. Meerts, R.J. Letcher, A.J. McAlee, B. Chittim, A. Brouwer, R.J. Norstrom

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Abstract

A new compound, 4-hydroxyheptachlorostyrene (4-OH-HpCS), was identified as a major component in the chlorinated phenolic compound fraction of polar bear plasma. The structure was hypothesized to be 4-OH-HpCS based on mass spectral interpretation, the assumption that it was a metabolite of octachlorostyrene, and the similarity of the structure to hydroxylated polychlorinated biphenyls (OH-PCBs) identified in plasma. High-resolution, electron impact (El) ionization mass spectrometry of the methylated compound indicated a molecular formula of C
Original languageEnglish
Pages (from-to)3871-3877
JournalEnvironmental Science and Technology
Volume34
Issue number18
DOIs
Publication statusPublished - 2000

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