Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime

N. Nikolic, D. Veselinovic, J. Vucina, H. Lingeman, K. Karljikovic-Rajic

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylalanine (l-DM-PhA), based on the ligand-exchange principle, has been applied. The separation is based on the presence of the immobilized binary complex Cu(l-DM-PhA)
Original languageEnglish
Pages (from-to)1159-66
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume32
Issue number6
DOIs
Publication statusPublished - 2003

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