Abstract
Beat-to-beat fluctuations of heart rate (HR) convey information of the brain state with the cardiac time series reflecting the flow of efferent nerve traffic of the autonomic nervous system. Instantaneous HR was studied in mice during exposure to novelty and the expression of fear conditioned to an auditory cue as affective challenge to characterize baseline dynamics and conditioned adjustments to learned fear. These studies included pharmacological and genetic interventions of brain systems implicated in aversive emotional states, the corticotropin-releasing factor (CRF) system and the serotonin (5-HT)
Original language | English |
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Pages (from-to) | 181-190 |
Number of pages | 9 |
Journal | Neuroscience and Biobehavioral Reviews |
Volume | 33 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2009 |