Assessing aversive emotional states through the heart in mice: implications for cardiovascular dysregulation in affective disorders

O. Stiedl, R.F. Jansen, A.W. Pieneman, S.O. Ogren, M. Meyer

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Beat-to-beat fluctuations of heart rate (HR) convey information of the brain state with the cardiac time series reflecting the flow of efferent nerve traffic of the autonomic nervous system. Instantaneous HR was studied in mice during exposure to novelty and the expression of fear conditioned to an auditory cue as affective challenge to characterize baseline dynamics and conditioned adjustments to learned fear. These studies included pharmacological and genetic interventions of brain systems implicated in aversive emotional states, the corticotropin-releasing factor (CRF) system and the serotonin (5-HT)
Original languageEnglish
Pages (from-to)181-190
Number of pages9
JournalNeuroscience and Biobehavioral Reviews
Volume33
Issue number2
DOIs
Publication statusPublished - 2009

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