Abstract
Folate overproduction can serve as a mode of resistance against the folate antagonist methotrexate in Lactobacillus plantarum WCFS1. When compared with a wild-type control strain, an engineered high folate-producing strain was found to be insensitive to methotrexate. The growth rate and the viable count of the folate-overproducing L. plantarum strain were not significantly affected by the presence of methotrexate in the growth medium. © 2009 Federation of European Microbiological Societies.
Original language | English |
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Pages (from-to) | 261-265 |
Journal | FEMS Microbiology Letters |
Volume | 297 |
DOIs | |
Publication status | Published - 2009 |