Folate overproduction in Lactobacillus plantarum WCFS1 causes methotrexate resistance.

H.B.A. Wegkamp, W.M. Vos, E.J. Smid

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Folate overproduction can serve as a mode of resistance against the folate antagonist methotrexate in Lactobacillus plantarum WCFS1. When compared with a wild-type control strain, an engineered high folate-producing strain was found to be insensitive to methotrexate. The growth rate and the viable count of the folate-overproducing L. plantarum strain were not significantly affected by the presence of methotrexate in the growth medium. © 2009 Federation of European Microbiological Societies.
    Original languageEnglish
    Pages (from-to)261-265
    JournalFEMS Microbiology Letters
    Volume297
    DOIs
    Publication statusPublished - 2009

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