TY - JOUR
T1 - Munc18-1 in secretion: lonely Munc joins SNARE team and takes control
AU - Toonen, R.F.G.
AU - Verhage, M.
PY - 2007
Y1 - 2007
N2 - SNARE proteins and the Sec1/Munc18 (SM) protein, Munc18-1, are essential components of the mammalian secretion machinery. Until recently, quite divergent working models existed for the central but rather isolated role of Munc18-1 in secretion and its relation to the SNAREs. New studies now solve old discrepancies, bring consensus among SM-SNARE interactions and emphasize how closely these proteins work together. Together, SM and SNARE proteins control each step in the exocytotic pathway as a team. Munc18-1 operates as the chief commander of the exocytotic SNARE team, making teamwork more efficient, working with specific team members on specific jobs, reducing promiscuity with members of noncognate teams, and adjusting team efforts as a function of recent history and environmental cues (presynaptic receptor activation). © 2007 Elsevier Ltd. All rights reserved.
AB - SNARE proteins and the Sec1/Munc18 (SM) protein, Munc18-1, are essential components of the mammalian secretion machinery. Until recently, quite divergent working models existed for the central but rather isolated role of Munc18-1 in secretion and its relation to the SNAREs. New studies now solve old discrepancies, bring consensus among SM-SNARE interactions and emphasize how closely these proteins work together. Together, SM and SNARE proteins control each step in the exocytotic pathway as a team. Munc18-1 operates as the chief commander of the exocytotic SNARE team, making teamwork more efficient, working with specific team members on specific jobs, reducing promiscuity with members of noncognate teams, and adjusting team efforts as a function of recent history and environmental cues (presynaptic receptor activation). © 2007 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.tins.2007.08.008
DO - 10.1016/j.tins.2007.08.008
M3 - Article
SN - 0166-2236
VL - 30
SP - 564
EP - 572
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 11
ER -