Abstract
Molecular genetic studies with strains of Escherichia coli resistant to triclosan, an ingredient of many anti-bacterial household goods, have suggested that this compound works by acting as an inhibitor of enoyl reductase (ENR) and thereby blocking lipid biosynthesis. We present structural analyses correlated with inhibition data, on the complexes of E. coli and Brassica napus ENR with triclosan and NAD
Original language | English |
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Pages (from-to) | 527-535 |
Number of pages | 9 |
Journal | Journal of Molecular Biology |
Volume | 294 |
DOIs | |
Publication status | Published - 1999 |