Crystallographic analysis of tricolosan bound to enoyl reductase.

A. Roujeinikova, C.W. Levy, S. Rowsell, S. Sedelnikova, P.J. Baker, C.A. Minshull, A. Mistry, J.G. Colls, R. Camble, A.R. Stuitje, A.R. Slabas, J.B. Rafferty, R.A. Pauptit, A Viner, D.W. Rice

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Molecular genetic studies with strains of Escherichia coli resistant to triclosan, an ingredient of many anti-bacterial household goods, have suggested that this compound works by acting as an inhibitor of enoyl reductase (ENR) and thereby blocking lipid biosynthesis. We present structural analyses correlated with inhibition data, on the complexes of E. coli and Brassica napus ENR with triclosan and NAD
    Original languageEnglish
    Pages (from-to)527-535
    Number of pages9
    JournalJournal of Molecular Biology
    Volume294
    DOIs
    Publication statusPublished - 1999

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