Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen.

J. Kool, R. Ramautar, S.M. van Liempd, J. Beckman, F.J.J. de Kanter, J.H.N. Meerman, T. Schenk, H. Irth, J.N.M. Commandeur, N.P.E. Vermeulen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Here we present a high-resolution screening (HRS) methodology for postcolumn on-line profiling of metabolites with affinity for the estrogen receptor α (ERα). Tamoxifen, which is metabolized into multiple metabolites, was used as the model compound. Most of the 14 metabolites detected exhibited affinity for the ERα. The HRS methodology shows great potential for metabolite bio-affinity profiling and application in drug discovery and development. © 2006 American Chemical Society.
Original languageEnglish
Pages (from-to)3287-3292
JournalJournal of Medicinal Chemistry
Volume49
Issue number11
DOIs
Publication statusPublished - 2006

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