On-line SPE-RP-LC for the determination of insulin derivatives in biological matrices

N.F.C. Visser, H. Lingeman, H. Irth

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

An automated and on-line solid-phase extraction (SPE)-liquid chromatography (LC) procedure is described for the determination of insulin in biological matrices. The total procedure consists of two SPEs in series, followed by RP-LC separation. During the first SPE a strong anion-exchange (SAX) cartridge (ISOLUTE, 40-90 μm, 10×4 mm i.d.) is used, followed by a RP-cartridge (Luna C
Original languageEnglish
Pages (from-to)295-309
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume32
Issue number2
DOIs
Publication statusPublished - 2003

Fingerprint

Dive into the research topics of 'On-line SPE-RP-LC for the determination of insulin derivatives in biological matrices'. Together they form a unique fingerprint.

Cite this