The interleukin-1 gene family in multiple sclerosis susceptibility and disease course.

T. van Veen, H.M. Schrijver, A. Zwiers, J.B.A. Crusius, D.L. Knol, N.F. Kalkers, M.L. Laine, F. Barkhof, A.S. Pena, C.H. Polman, B.M.J. Uitdehaag

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Multiple sclerosis (MS) is a chronic disease of presumed autoimmune origin with a considerable polygenic influence. We have previously observed that a specific allele combination in genes of the interleukin-1 (IL-1) family influenced the progression rate in MS. We have considerably expanded our patient population (492 MS patients and 228 controls). In the present study, we investigated the role of the IL-IA--889, IL-1B--511, IL-1B f3953 and IL-1RN VNTR gene polymorphisms in MS. In addition, we performed preliminary analyses on longitudinal magnetic resonance imaging (MRI) data. We found no associations between the polymorphisms and susceptibility to MS or clinical features. In addition, we observed no significant effect of the polymorphisms on brain or lesion volumes, Based on our data and those from the literature, one can conclude that there is currently no evidence to support a role for the IL-1 genes in MS.
Original languageEnglish
Pages (from-to)535-9
JournalMultiple Sclerosis
Volume9
Issue number6
Early online date1 Dec 2003
DOIs
Publication statusPublished - 2003
Externally publishedYes

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