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dc.contributor.authorMebius, R.E.en_US
dc.date.accessioned2011-11-14T14:28:14Z
dc.date.issued2003en_US
dc.identifier.citationNature Reviews Immunology, 3(4), 292-303en_US
dc.identifier.issn1474-1733
dc.identifier.urihttp://hdl.handle.net/1871/25989
dc.description.abstractThe development of lymphoid organs depends on the correct expression of several molecules within a defined timeframe during ontogeny. Although this is an extremely complex process, with each secondary lymphoid tissue requiring subtly different signals, a common framework for lymphoid development is beginning to emerge. Drawing on studies of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines, which emphasizes the role of interactions between CD3-CD4+CD45+ 'inducer' cells and VCAM1+ICAM1+ stromal 'organizer' cells is presented.en_US
dc.relation.uri10.1038/nri1054
dc.titleOrganogenesis of lymphoid tissues.en_US
dc.typeArticle / Letter to editoren_US
dc.creator.metisIdVU1015772
dc.identifier.metisId165598
dc.provenance.metis2004-03-30 11:39
dc.source.volume3
dc.source.journalTitleNature Reviews Immunologyen_US
dc.source.startpage292
dc.source.endpage303
dc.source.issue4
dc.creator.facultyVU medisch centrumnl_NL
dc.coverage.researchinstituteO 00107nl_NL
dc.date.updated2014-02-07T10:13:09Z


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