Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates.

J.N.M. Commandeur, L.J. King, L. Koymans, N.P.E. Vermeulen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The covalent binding of reactive intermediates, formed by β-elimination of cysteine S-conjugates of halogenated alkenes, to nucleophiles was studied using
Original languageEnglish
Pages (from-to)1092-1102
JournalChemical Research in Toxicology
Volume9
DOIs
Publication statusPublished - 1996

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