Nuclear and nucleolar localization of Saccharomyces cerevisiae ribosomal proteins S22 and S25

A.C.J. Timmers, R. Stuger, P.J. Schapp, J. van 't Riet, H.A. Raué

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Nuclear import usually relies on the presence of nuclear localization sequences (NLSs). NLSs are recognized by NLS receptors (importins), which target their substrates to the nuclear pore. We identified the NLSs of the yeast ribosomal proteins S22 and S25 and studied the former by mutational analysis. Furthermore, in S25 the nucleolar targeting information was found to overlap with its NLS. Comparison with previously published data on yeast ribosomal protein NLSs and computer analysis indicates the existence of a novel type of ribosomal protein-specific NLS that differs from the classical Chelsky and bipartite NLSs. The existence of such a ribosomal protein-specific NLS is in accordance with the recent identification of ribosomal protein-specific importins. Copyright (C) 1999 Federation of European Biochemical Societies.
Original languageEnglish
Pages (from-to)335-340
JournalFEBS Letters
Volume452
DOIs
Publication statusPublished - 1999

Fingerprint

Dive into the research topics of 'Nuclear and nucleolar localization of Saccharomyces cerevisiae ribosomal proteins S22 and S25'. Together they form a unique fingerprint.

Cite this