TY - JOUR
T1 - Age dependence of plasma phospholid fatty acid levels: potential role of linoleic acid in the age-associated increase in docosahexaenoic acid and eicosapentaenoic acid concentrations
AU - Groot, R.H.M.
AU - van Boxtel, M.P.J.
AU - Schiepers, O.J.G.
AU - Hornstra, G.
AU - Jolles, J.
PY - 2009
Y1 - 2009
N2 - Limited information is available with respect to the association between age and the plasma phospholipid fatty acid profile. Therefore we investigated the association between plasma phospholipid fatty acid status and age after correction for sex, smoking, alcohol use, BMI and fish intake. Plasma phospholipid fatty acid composition was measured and information on fish intake and other potential covariates was collected in 234 participants of the Maastricht Aging Study. The participants were healthy individuals of both sexes with an age range between 36 and 88 years. Hierarchical linear regression analyses were applied to study the relationship between age and fatty acid concentrations. After correction for fish consumption and other relevant covariates, a significant positive relationship was observed between age of the subjects and their plasma phospholipid concentrations of DHA (22:6n-3, P=0.006) and EPA (20:5n-3; P=0.001). Age contributed 23 and 39% to the amount of explained variance, respectively. The higher n-3 long-chain PUFA status at advanced age was confirmed by lower concentrations of their putative shortage marker Osbond acid (ObA, 22:5n-6; P=0.022 for the relationship with age after correction for covariates and fish intake, R
AB - Limited information is available with respect to the association between age and the plasma phospholipid fatty acid profile. Therefore we investigated the association between plasma phospholipid fatty acid status and age after correction for sex, smoking, alcohol use, BMI and fish intake. Plasma phospholipid fatty acid composition was measured and information on fish intake and other potential covariates was collected in 234 participants of the Maastricht Aging Study. The participants were healthy individuals of both sexes with an age range between 36 and 88 years. Hierarchical linear regression analyses were applied to study the relationship between age and fatty acid concentrations. After correction for fish consumption and other relevant covariates, a significant positive relationship was observed between age of the subjects and their plasma phospholipid concentrations of DHA (22:6n-3, P=0.006) and EPA (20:5n-3; P=0.001). Age contributed 23 and 39% to the amount of explained variance, respectively. The higher n-3 long-chain PUFA status at advanced age was confirmed by lower concentrations of their putative shortage marker Osbond acid (ObA, 22:5n-6; P=0.022 for the relationship with age after correction for covariates and fish intake, R
U2 - 10.1017/S0007114509359103
DO - 10.1017/S0007114509359103
M3 - Article
SN - 0007-1145
VL - 102
SP - 1058
EP - 1064
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 7
ER -