TY - JOUR
T1 - Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids
AU - Lozovaya, N.
AU - Yatsenko, N.
AU - Beketov, A.
AU - Tsintsadze, T.
AU - Burnashev, N.
PY - 2005
Y1 - 2005
N2 - At many central synapses, endocannabinoids released by postsynaptic cells act retrogradely on presynaptic G-protein-coupled cannabinoid receptors to inhibit neurotransmitter release. Here, we demonstrate that cannabinoids may directly affect the functioning of inhibitory glycine receptor (GlyR) channels. In isolated hippocampal pyramidal and Purkinje cerebellar neurons, endogenous cannabinoids anandamide and 2-arachidonylglycerol, applied at physiological concentrations, inhibited the amplitude and altered the kinetics of rise time, desensitization, and deactivation of the glycine-activated current (I
AB - At many central synapses, endocannabinoids released by postsynaptic cells act retrogradely on presynaptic G-protein-coupled cannabinoid receptors to inhibit neurotransmitter release. Here, we demonstrate that cannabinoids may directly affect the functioning of inhibitory glycine receptor (GlyR) channels. In isolated hippocampal pyramidal and Purkinje cerebellar neurons, endogenous cannabinoids anandamide and 2-arachidonylglycerol, applied at physiological concentrations, inhibited the amplitude and altered the kinetics of rise time, desensitization, and deactivation of the glycine-activated current (I
U2 - 10.1523/JNEUROSCI.0977-05.2005
DO - 10.1523/JNEUROSCI.0977-05.2005
M3 - Article
SN - 0270-6474
VL - 25
SP - 7499
EP - 7506
JO - The Journal of Neuroscience
JF - The Journal of Neuroscience
IS - 33
ER -