Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids

N. Lozovaya, N. Yatsenko, A. Beketov, T. Tsintsadze, N. Burnashev

Research output: Contribution to JournalArticleAcademicpeer-review

156 Downloads (Pure)

Abstract

At many central synapses, endocannabinoids released by postsynaptic cells act retrogradely on presynaptic G-protein-coupled cannabinoid receptors to inhibit neurotransmitter release. Here, we demonstrate that cannabinoids may directly affect the functioning of inhibitory glycine receptor (GlyR) channels. In isolated hippocampal pyramidal and Purkinje cerebellar neurons, endogenous cannabinoids anandamide and 2-arachidonylglycerol, applied at physiological concentrations, inhibited the amplitude and altered the kinetics of rise time, desensitization, and deactivation of the glycine-activated current (I
Original languageEnglish
Pages (from-to)7499-7506
Number of pages8
JournalThe Journal of Neuroscience
Volume25
Issue number33
DOIs
Publication statusPublished - 2005

Fingerprint

Dive into the research topics of 'Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids'. Together they form a unique fingerprint.

Cite this