Abstract
Background: A recent modeling study by the authors predicted that contextual information is poorly integrated into episodic representations in schizophrenia, and that this is a main cause of the retrieval deficits seen in schizophrenia. & Methodology/Principal Findings: We have tested this prediction in patients with first-episode schizophrenia and matched controls. The benefit from contextual cues in retrieval was strongly reduced in patients. On the other hand, retrieval based on item cues was spared. & Conclusions/Significance: These results suggest that reduced integration of context information into episodic representations is a core deficit in schizophrenia and one of the main causes of episodic memory impairment. © 2010 Talamini.
Original language | English |
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Pages (from-to) | e10356 |
Number of pages | 7 |
Journal | PLoS ONE |
Volume | 5 |
DOIs | |
Publication status | Published - 2010 |