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dc.contributor.authorLiempt, P.A.G. vanen
dc.date.accessioned2007-03-12T12:08:30Z
dc.date.available2007-03-12T12:08:30Z
dc.date.issued2007-03-15en
dc.identifier.urihttp://hdl.handle.net/1871/10702
dc.description.abstractOutline of this thesis The studies described in this thesis have been performed to gain more insight in the recognition of Schistosoma mansoni glycans by C-type lectins and the consequences for dendritic cell mediated immune responses. As a first approach to understand the molecular interactions of schistosome glycans and dendritic cells that lead to TH2 cell polarization, the recognition of schistosome glycan antigens by DCs were investigated. In chapter 2 and 3 we describe the carbohydrate specificity of DC-SIGN and MGL respectively, by performing a glycan array using an Fc-chimera. Next, the molecular basis of differences in carbohydrate binding properties of DC-SIGN and its homologue L-SIGN were investigated in chapter 4. The interaction of DC-SIGN with self- glycoproteins was analyzed in chapter 5, by determining the DC-SIGN ligands that are crucial for the adhesion and rolling of dendritic cells on endothelial cells, a prerequisite for migration of DCs to the lymph node. The interactions of DC-SIGN with glycolipids of different life stages of the human parasite Schistosoma mansoni were investigated in chapter 6. In chapter 7 we demonstrate that Schistosoma mansoni soluble egg antigens are recognized by several C-type lectins on dendritic cells and suppress TLR- induced DC maturation. Finally, the results presented in this thesis are integrated in a general discussion and main perspectives for future studies are discussed in chapter 8.en
dc.description.sponsorshipKooyk, Y. van [Promotor]en_US
dc.description.sponsorshipDie, I.M. van [Copromotor]en_US
dc.format.extent4950290 bytes
dc.format.extent7614692 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherAmsterdam: Vrije Universiteiten
dc.subjectRecognition of carbohydrates on schistosome soluble egg antigens by human dendritic cells; molecular basis and functionen
dc.subjectDendritische cellenen
dc.subjectC-type Lectinsen
dc.subjectSchistosoma mansonien
dc.subjectsoluble egg antigensen
dc.titleC-type lectin interactions with Schistosoma mansoni SEA : Molecular basis and functionen
dc.typeDoctoral thesisen


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